A REVIEW ON FLOATING DRUG DELIVERY SYSTEMS
Keywords:
Fasted state, gastric residence time, gastroretention, gastrointestinal tract, narrow absorption windowAbstract
The oral route is considered as the most promising route of drug delivery. Conventional drug delivery system achieves as well as maintains the drug concentration within the therapeutically effective range needed for treatment, only when taken several times a day. This results in a significant fluctuation in drug levels. Recently, several technical advancements had introduced. The idea of gastric retention comes from the need to localize drugs at a specific region of gastrointestinal tract (GIT) such as stomach in the body. Many drugs get absorbed only in the upper intestinal tract, designing such molecules as once-daily formulations are exclusive for these molecules. Thus GI retention platforms had emerged. One of the major challenges in developing gastric retention device is overcoming the house keeping waves particularly in the fasted state. Often, the extent of drug absorption is limited by the gastric residence time (GRT) of the drug at the absorption site. If the drugs are poorly soluble in intestine due to alkaline pH, gastric retention may increase solubility before they are emptied, resulting in improved gastrointestinal absorption of drugs with narrow absorption window as well as for controlling release of drugs having site-specific absorption limitation. Gastroretention would also facilitate local drug delivery to the stomach and proximal small intestine. Thus, gastroretention could help to provide greater availability of new products and consequently improved therapeutic activity and substantial benefits to patients.
KEY WORDS
Fasted state, gastric residence time, gastroretention, gastrointestinal tract, narrow absorption window.
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