METHANOLIC EXTRACTION OF WHOLE DRIED FRUIT OF PUNICA GRANATUM AND EVALUATION FOR ITS ANTI MICROBIAL ACTIVITY
Keywords:
Extracts, Punica granatum, methanolic, etc.Abstract
Plants have associate degree nearly limitless ability to synthesize aromatic substances, most of that area unit phenols or their oxygen-substituted derivatives. Most area unit secondary metabolites, of that a minimum of twelve, 000 are isolated, variety calculable to be but 100 percent of the overall. In several cases, these substances’ function plant defense mechanisms against predation by microorganisms, insects, and herbivores. Some, like terpenoids, provide plants their odors; others (quinones and tannins) area unit liable for plant pigment. several compounds area unit liable for plant flavor (e.g., the terpenoid chemical irritant from chili peppers), and a few of an equivalent herbs and spices utilized by humans to season food yield helpful medicative compounds. In the present work an attempt was made to evaluate the anti-microbial activity of the Punica granatum, similar works have been performed by various scientists around the world but not used fruit as a whole extract in this work methanolic extracts of whole dried fruits are used and the results are found to be better than that of the extracts prepared from only seeds, peels, rind. The extracts from whole fruit showed better results but didn’t cross the standard drugs results but by a minor margin.
References
Abou-Karam M, Shier W T. A simplified plaque reduction assay for antiviral agents from plants. Demonstration of frequent occurrence of antiviral activity in higher plants. J Nat Prod. 1990; 53:340-344. [PubMed]
Afolayan A J, Meyer J J M. The antimicrobial activity of 3,5,7-trihydroxyflavone isolated from the shoots of Helichrysum aureonitens. J Ethnopharmacol. 1997; 57:177–181. [PubMed]
Ahmad A, Davies J, Randall S, Skinner G R B. Antiviral properties of extract of Opuntia streptacantha. Antiviral Res. 1996; 30:75–85. [PubMed]
Ahmed A A, Mahmoud A A, Williams H J, Scott A I, Reibenspies J H, Mabry T J. New sesquiterpene α methylene lactones from the Egyptian plant Jasonia candicans. J Nat Prod. 1993; 56:1276–1280. [PubMed]
Akpata E S, Akinrimisi E O. Antibacterial activity of extracts from some African chewing sticks. Oral Surg Oral Med Oral Pathol. 1977; 44:717–722. [PubMed]
Ali-Shtayeh M S, Al-Nuri M A, Yaghmour R M R, Faidi Y R. Antimicrobial activity of Micromeria nervosa from the Palestinian area. J Ethnopharmacol. 1997; 58:143–147. [PubMed]
Alper J. Effort to combat microbial resistance lags. ASM News. 1998; 64:440–441. Amaral J A, Ekins A, Richards S R, Knowles R. Effect of
selected monoterpenes on methane oxidation, denitrification, and aerobic metabolism by bacteria in pure culture. Appl Environ Microbiol. 1998; 64:520 525. [PMC free article] [PubMed]
Amoros M, Sauvager F, Girre L, Cormier M. In vitro antiviral activity of propolis. Apidologie. 1992; 23:231–240.
Amoros M, Simoes C M O, Girre L. Synergistic effect of flavones and flavonols against herpes simplex virus type 1 in cell culture. Comparison with the antiviral activity of propolis. J Nat Prod. 1992; 55:1732–1740. [PubMed]
Anonymous. Commission on Dietary Supplement Labels issues final report. J Am Diet Assoc. 1998; 98:270. [PubMed]
Anonymous. FANSA releases statement about dietary supplement labeling. J Am Diet Assoc. 1997; 97:728
729.
Anonymous. First IND submitted with FDA for an herbal pharmaceutical. AIDS Weekly Plus 18. 1997.
Apisariyakul A, Vanittanakom N, Buddhasukh D. Antifungal activity of turmeric oil extracted from Curcuma longa (Zingiberaceae) J thnopharmacol. 1995; 49:163–169. [PubMed]
Atta-ur-Rahman M I, Choudhary Diterpenoid and steroidal alkaloids. Nat Prod Rep. 1995; 12:361–379. [PubMed]
Aureli P, Costantini A, Zolea S. Antimicrobial activity of some plant essential oils against Listeria monocytogenes. J Food Prot. 1992; 55:344–348.
Avorn J. The effect of cranberry juice on the presence of bacteria and white blood cells in the urine of elderly women. What is the role of bacterial adhesion? Adv Exp Med Biol. 1996; 408:185–186. [PubMed]
Ayafor J F, Tchuendem M H K, Nyasse B. Novel bioactive diterpenoids from Aframomum aulacocarpos. J Nat Prod. 1994;57:917–923.
[PubMed]
Balls A K, Hale W S, Harris T H. A crystalline protein obtained from a lipoprotein of wheat flour. Cereal Chem. 1942; 19:279–288.
Balzarini J, Schols D, Neyts J, Van Damme E, Peumans W, De Clercq E. α-(1,3)- and α-(1,6)-d-mannose specific plant lectins are markedly inhibitory to human immunodeficiency virus and cytomegalovirus infections in vitro. Antimicrob Agents Chemother. 1991; 35:410–416. [PMC free article] [PubMed]
Barnard D L, Huffman J H, Meyerson L R, Sidwell R W. Mode of inhibition of respiratory syncytial virus by a plant flavonoid. Chemotherapy. 993; 39:212–217. [PubMed]
Barre J T, Bowden B F, Coll J C, Jesus J, Fuente V E, Janairo G C, Ragasa C Y. A bioactive triterpene from Lantana camara. Phytochemistry. 1997; 45:321–324. [PubMed]
Downloads
Published
License
Copyright (c) 2026 INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND BIOMEDICAL ANALYSIS

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
![]()

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. Based on a work at www.ijprba.com
"The content of IJPRBA journal and the published Manuscripts are copy right protected. Commercial usage of the same is prohibited.
Click here for obtaining Permission for commercial use"


