SYNTHESIS AND SCREENING OF ANTIINFLAMMATORY ACTIVITY OF INDOLE DERIVATIVES
Keywords:
Synthesis, 5-[2(3)-dialkyl amino alkoxy] Indole 2, 3-diones, 5-Hydroxyindole 3-semicarbazone 2-ones, Antiinflammatory activityAbstract
In the present work, some new 5-[2(3)-dialkylamino alkoxy] Indole 2, 3-diones and 5-Hydroxyindole 3-semicarbazone 2-ones were prepared from 5-hydroxy isatin. The structures of the products were characterized by IR, NMR, MASS Spectral studies Thus synthesized and characterized targetted compounds were further screened for their anti-inflammatory activity by using Carrageenan - induced paw edema rat model. Among all the newly synthesized derivatives, Compounds IIIa-b and Compounds IVa-b were reduced the inflammation very significantly , thus these compounds showed promising anti-inflammatory activity and compounds IIIc-e & IVc-e showed moderate anti-inflammatory activity.
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