PHARMACOGNOSY, PHYTOCHEMISTRY AND PHARMACOLOGICAL PROFILE OF Cissus quadrangularis
Keywords:
Cissus quadrangularis, FractureAbstract
Cissus quadrangularis, commonly known as Hadjod, is a popular folklore medicine used throughout India by bone setters. It is highly studied for its bone healing potential. Its remarkable properties are mentioned in Ayurveda and Unani medicine. Apart from the popular medicinal uses, many other aspects of this wonder plant are less popular. The present article provides the complete pharmacognostic, phytochemical, and pharmacological profiles of the Cissus quadrangularis.
References
1. Frank S, Hubner G, Breier G, Longaker MT, Greenhalgh DG, Werner S. Regulation of Vascular Endothelial Growth Factor Expression in Cultured Keratinocytes, The J Biological Chemistry. 1995; 270(21):2607-12613.
2. Chopra R.N., Nayar S.L. and Chopra I.C., Glossary of Indian Medicinal Plants, National Institute of Science and Communication, CSIR, New Delhi, 1986, 66-67.
3. Shirwaikar A, Khan S, Malini S. Antiosteoporotic effect of ethanol extract of Cissus quadrangularis Linn. on ovariectomized rat. J Ethnopharmacol. 89(2-3), 2003, 245-50.
4. Jaiswal S, Singh SV, Singh B, Singh HN. Plants used for tissue healing of animals. Natural Products Radiance. 2004; 3: 284-92.
5. Luseba D, Elgorashi EE, Ntloedibe DT, Staden JV. Antibacterial, anti-inflammatory and mutagenic effects of some medicinal plants used in South Africa for the treatment of wounds and retained placenta in livestock. South African Journal of Botany. 2007; 73: 378-83.
6. Mallika J, Shyamala Devi CS. In vitro and In vivo evaluation of free radical scavenging potential of Cissus quadrangularis. African Journal of Biomedical Research. 2005; 8: 95 99.
7. Shirwaikar A, Khan S, Malini S. Antiosteoporotic effect of ethanol extracts of Cissus quadrangularis Linn on ovariectomized rat. Journal of Ethnophramacology. 2003; 89:245-50.
8. Udupa, K.N., Chaturvedi, G.N., Tripathi, S.N.: Advances in research in Indian medicine: Banaras Hindu University, Varanasi, 12:165–96 (1970).
9. Dr. Mohd. Ataullah Shareef, Kitabul Advia Mufarradaath. Best Printers and Publishers- Hyderabad, First edition. 2012, 511-512.
10. Barzini P, Mazzucco I. Platelet-rich plasma (PRP) and platelet derivatives for topical therapy. What is true from the biologic viewpoint, ISBT Science Series, 2007; (2):272281.
11. Rastogi RP, Mehrotra BN. Compendium of Indian Medicinal Plants, Part I, Publication and information directorate 1995, 104.
12. Chopra N.N., Chopra I.C., Handa K.L., Kapur L.D., Cissus quadrangularis. Indigenous Drugs of India, 1958, 669–670.
13. Rajpal V. Standardization of Botanicals. Eastern Publishers 2005. Vol 1, p. 77-81.
14. Warrier, P.K., Nambiar, V.P.K., & Raman Kutty, C. (1995). Indian Medicinal Plants: A Compendium of 500 Species, Vol. 2. Orient Longman.
15. Jainu M., Devi CS. “Effect of Cissus quadrangularis on gastric mucosal defensive factors in experimentally induced gastric ulcer- a comparative study with Sucralfate”. Journal of medicinal food. 2004; 7(3):372-376.
16. Chidambara Murthy KN, Vanitha A, Mahadeva Swamy M, Ravishankar GA. Antioxidant and antimicrobial activity of Cissus quadrangularis L. J Med Food. 2003;6(2):99-105.
17. Panthong, A., Kanjanapothi, D., Taesotikul, T., et al. (2007). Anti-inflammatory activity of Cissus quadrangularis extract in rats. Fitoterapia, 78(6), 453–458.
18. Asha Jyothi. V* and Sneha Chittari, Role of Nutrition in Osteoporosis, JCHPS (2025) 18 (2): 01-05.
19. Udupa KN et al., 1964; Paris and Moyse, 1971
20. Jainu M & Devi CS, Journal of Ethnopharmacology, 2005.
21. Chidambara Murthy KN et al., 2003 (Plant Foods for Human Nutrition)
22. Ashajyothi.V, Dr. Rao. S. Pippalla and Dr. Satyavati D, Antioxidant Activity of Few Phytoestogens by Dpph Assay, IJPT, 2013, 5 (3), 5868-5872.
23. Oben J et al., 2006. Lipids in Health and Disease, 5(1): 24.
24. Panthong A et al., 2007; Balasubramanian T et al., 2010.
25. Panda S et al., 2008. Indian Journal of Pharmacology, 40(3): 129–132.
26. Prasad GC et al., 1993. Journal of Ethnopharmacology, 40(2): 131–136.
27. Panthong et al., 2007; Chidambara Murthy et al., 2003
28. Chidambara Murthy, K. N., Vanitha, A., Mahadeva Swamy, M., Ravishankar, G. A. (2003). Antioxidant and antimicrobial activity of Cissus quadrangularis L. Journal of Medicinal Food, 6(2), 99–105.
29. Udupa, K. N., Prasad, G. C. (1964). Further studies on the effect of Cissus quadrangularis in accelerating fracture healing. Indian Journal of Medical Research, 52, 26–35.
30. Reanin Research (2024). Global Cissus Quadrangularis Market Report. https://www.reanin.com
31. Future Market Insights (2024). Cissus Quadrangularis Market Forecast. https://www.futuremarketinsights.com
32. Reanin Research. (2024). Global Cissus Quadrangularis Market Report (2024–2031).
33. Jainu, M., & Devi, C. S. S. (2004). Gastroprotective action of Cissus quadrangularis extract against aspirin-induced gastric mucosal injury. Journal of Ethnopharmacology, 93(2-3), 261–266.
34. Sampath Kumar, S., et al. (2015). Clinical evaluation of Cissus quadrangularis as osteogenic agent in mandibular fracture. Journal of Natural Science, Biology and Medicine, 6(2), 333–336.
35. Benjawan, S., et al. (2022). The effect of Cissus quadrangularis L. on delaying bone loss in postmenopausal women with osteopenia: A randomized placebo-controlled trial. Phytomedicine, 101, 154115.
36. Vaijayanthimala, R., et al. (2018). In vitro anti-arthritic activity of Cissus quadrangularis stem extract. Asian Journal of Pharmaceutical and Clinical Research, 11(1), 273–275.
37. Srisook, K., et al. (2011). Anti-inflammatory effect of ethyl acetate extract from Cissus quadrangularis Linn may be involved with induction of heme oxygenase-1 and suppression of NF-κB activation. Journal of Ethnopharmacology, 133(3), 1008–1014.
38. Jainu, M., & Devi, C. S. S. (2004). Gastroprotective action of Cissus quadrangularis extract against aspirin-induced gastric mucosal damage in rats. Journal of Ethnopharmacology, 93(2–3), 261–266.
39. Jainu, M., et al. (2014). Cissus quadrangularis extract attenuates hyperglycaemiamediated oxidative stress in streptozotocin-induced diabetic rats. Journal of Pharmacy and Pharmacology, 66(6), 829–838.
40. Subramani, R., et al. (2018). Analysis of potential toxicological, phytochemical, and anticancer activity of Cissus quadrangularis extract. Research Journal of Life Sciences, Bioinformatics, Pharmaceutical and Chemical Sciences, 4(1), 241–252.
41. Moto, F. C. O., Arsa’a, A., Ngoupaye, G. T., Taiwe, G. S., Njapdounke, J. S. K., Kandeda, A. K., Nkantchoua, G. C. N., Omam Omam, J. P., Pale, S., Kouemou, N. E., Ayissi Mbomo, E. R., Pahaye, D. B., Ojong, L., Mairara, V., & Ngo Bum, E. Frontiers in Pharmacology, 2018, 9, 751.
42. Dhanasekaran, S. (2020). Phytochemical characteristics of aerial part of Cissus quadrangularis (L) and its in-vitro inhibitory activity against leukemic cells and antioxidant properties. Saudi Journal of Biological Sciences, 27(5), 1302–1309.
43. Olga, M., et al. (2024). Ethanolic extracts of Cissus quadrangularis Linn. attenuate vincristine-induced peripheral neuropathy in rats: An evidence of the antioxidant, calcium inhibitory, and neuromodulatory properties. Advances in Pharmacological and Pharmaceutical Sciences, 2024, 8822369.
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