PHARMACOGNOSY, PHYTOCHEMISTRY AND PHARMACOLOGICAL PROFILE OF Mentha Piperita (PEPPERMINT)
Keywords:
Mentha piperita, Mint, Peppermint, Menthol, Medicinal benefitsAbstract
Mint is a very popular household plant in Indian communities and is used daily as a condiment in every house. Mint has much more than just a condiment and holds medicinal value due to its volatile oil content. The present article is a review of the pharmacognosy, phytochemistry and pharmacology of Mint.
References
1. Saller R, "Peppermint (Mentha piperita), medicinal plant of the year 2004", Forsch Komplementarmed Klass Naturheilkd, 2004, 11, (1) 6–7.
2. Frampton A, The Complete Illustrated Book of Herbs, The Reader's Digest Association, 2011.
3. Peppermint", Botanical Online, 2018.
4. Euro+Med Plantbase Project, "Mentha × piperita", 2012.
5. Mimica-Dukic N, Bozin B, "Mentha L. species (Lamiaceae) as promising sources of bioactive secondary metabolites", Current Pharmaceutical Design, 2008, 14, (29), 3141–3150.
6. Mentha and Schizonepeta", ITM Online, 2018.
7. Bone K, Mills SY, Principles and Practice of Phytotherapy: Modern Herbal Medicine, 2nd ed., Churchill Livingstone, 2013.
8. Chaudhary K, Parihar S, Sharma D, "A Critical Review on Nanoscience Advancement: In Treatment of Viral Infection", Journal of Drug Delivery and Therapeutics, 2021, 11, (6), 225–237.
9. Wu Z, Tan B, Liu Y, Dunn J, Martorell Guerola P, Tortajada M, Cao Z, Ji P, "Chemical Composition and Antioxidant Properties of Essential Oils from Peppermint, Native Spearmint and Scotch Spearmint", Molecules, 2019, 24, (15), 2825.
10. Abbas S, Sultana S, Chishti AW, Akram M, Ali Shah SMA, Sareen A, Siddique S, Aftab A, "Mentha piperita: Medicinal uses and pharmacological properties", International Journal of Scholarly Research in Biology and Pharmacy, 2022, (1), 41–45.
11. American Botanical Council, "Expanded Commission E Monographs: Peppermint Oil", 2023.
12. Ahmad RS, Imran A, Arshad MS, Hussain MB, Waheed M, Safdar S, Yasmin Z, "Introductory chapter: Mentha piperita (a valuable herb): Brief overview", Herbs Spices, 2020.
13. https://en.wikipedia.org/wiki/Peppermint
14. Kokate CK, Purohit AP, Gokhale SB, Pharmacognosy, 49th ed., Nirali Prakashan, 2014.
15. Evans WC, Trease and Evans' Pharmacognosy, 16th ed., Elsevier, 2009.
16. Hossain MA, Al-Hdhrami SS, Weli AM, Al-Riyami Q, Al-Sabahi JN, "Isolation, fractionation and identification of chemical constituents from the leaves crude extracts of Mentha piperita L grown in Sultanate of Oman", Asian Pacific Journal of Tropical Biomedicine, 2014, 4, Suppl 1, S368–S372.
17. Moghaddam M, Pourbaige M, Tabar HK, Farhadi N, Hosseini SMA, "Composition and antifungal activity of peppermint (Mentha piperita) essential oil from Iran", Journal of Essential Oil-Bearing Plants, 2013, 16, 4, 506–512.
18. Pandey A, Rai M, Acharya D, "Chemical composition and antimycotic activity of the essential oils of corn mint (Mentha arvensis) and lemon grass (Cymbopogon flexuosus) against human pathogenic fungi", Pharmaceutical Biology, 2003, 41, (6), 421–425.
19. Soltanbeigi A, Özgüven M, Hassanpouraghdam MB, "Planting-date and cutting-time affect the growth and essential oil composition of Mentha × piperita and Mentha arvensis", Industrial Crops and Products, 2021, 170, 113790.
20. Olennikov D, Tankhaeva L, "Quantitative determination of phenolic compounds in Mentha piperita leaves", Chemistry of Natural Compounds, 2010, 46, (1), 22–27.
21. Balakrishnan A, "Therapeutic uses of peppermint – A review", Journal of Pharmaceutical Sciences and Research, 2015, 7, (7), 474–476.
22. Pimentel M, Kong Y, Park S, "Breath testing to evaluate lactose intolerance in irritable bowel syndrome correlates with lactulose testing and may not reflect true lactose malabsorption", American Journal of Gastroenterology, 2003, 98, (12), 2700–2704.
23. Jain D, Pathak N, Khan S, Raghuram GV, Bhargava A, Samarth R, et al., "Evaluation of cytotoxicity and anticarcinogenic potential of Mentha leaf extracts", International Journal of Toxicology, 2011, 30, (3), 225–236.
24. Seif Sahandi, M., Mehrafarin, A., Khalighi-Sigaroodi, F., Sharifi, M., & Naghdi Badi, H. (2019). Review on Anatomical, Phytochemical and Pharmacological Properties of Peppermint (Mentha piperita L.). Journal of Medicinal Plants, 18(69), 16–33.
25. Khanna R, MacDonald JK, Levesque BG, "Peppermint oil for the treatment of irritable bowel syndrome: a systematic review and meta-analysis", Journal of Clinical Gastroenterology, 2014, 48, (6), 505–512.
26. Barbalho SM, Damasceno DC, Spanda AP, da Silva VS, Martuchi KA, Oshiiwa M, et al., "Metabolic profile of offspring from diabetic Wistar rats treated with Mentha piperita (peppermint)", Evidence-Based Complementary and Alternative Medicine, 2011, 2011, Article ID 430237.
27. Sharma A, Sharma MK, Kumar M, "Protective effect of Mentha piperita against arsenic-induced toxicity in liver of Swiss Albino mice", Basic & Clinical Pharmacology & Toxicology, 2007, 100, (4), 249–257.
28. Sevindik M, "Pharmacological properties of Mentha species", Journal of Traditional Medicine & Clinical Naturopathy, 2018, (7), 259.
29. Seif Sahandi, M., Mehrafarin, A., Khalighi-Sigaroodi, F., Sharifi, M., & Naghdi Badi, H. (2019). Review on Anatomical, Phytochemical and Pharmacological Properties of Peppermint (Mentha piperita L.). Journal of Medicinal Plants, 18(69), 16–33.
30. Soares GA, Bhattacharya T, Chakrabarti T, Tagde P, Cavalu S, "Exploring pharmacological mechanisms of essential oils on the central nervous system", Plants, 2022, 11, (1), 21.
31. Kaur P., Davar V., Exploring the nutraceutical and therapeutic potential of commonly used Indian spices, International Journal of Physiology, 2018, 3, (2), 410–419.
32. Spirling, L. I., & Daniels, I. R. (2001). Botanical perspectives on health: Peppermint—More than just an after-dinner mint. Perspectives in Public Health, 121(1), 62–63.
33. Rogers J., Tay H.H., Misiewicz J.J., Bell G.D., Peppermint oil, The Lancet, 1988, 332, 8600, 98–99.
34. McKay, D. L., & Blumberg, J. B., A review of the bioactivity and potential health benefits of peppermint tea (Mentha piperita L.). Phytotherapy Research, 2006, 20(8), 619–633.
35. Sharangi A.B., Guha S., Wonders of leafy spices: Medicinal properties ensuring human health, Science International, 2013, (1), 312–317.
36. Kothari S., Sharma S., Sharma S., Phytoconstituents and medicinal value of Mentha piperita, Phytomorphology, 2018, 68, (1), 1–8.
37. Jissa G., Sai-Sailesh K., Mukkadan J.K., Oral administration of nutmeg on memory boosting and regaining in Wistar albino rats, Bali Medical Journal, 2014, 3, (3), 3–10.
38. Hirohisa Takano, Naomi Osakabe, Chiaki Sanbongi, Rie Yanagisawa, Ken-ichiro Inoue, Akiko Yasuda, Midori Natsume, Seigo Baba, Ei-ichiro Ichiishi, Toshikazu Yoshikawa, Extract of Perilla frutescens Enriched for Rosmarinic Acid, a Polyphenolic Phytochemical, Inhibits Seasonal Allergic Rhinoconjunctivitis in Humans, Journal of Allergy and Clinical Immunol, 2004, 113, (2), 272–278.
39. Huang K.J., et al., Toxicological assessment of peppermint oil: A review, Food and Chemical Toxicology, 2009, 47, (2), 316–322.
40. De Groot A.C., Contact allergy to essential oils, Dermatitis, 2016, 27, 4, 170–175.
41. Asero R., Mistrello G., Roncarolo D., Amato S., A case of peppermint allergy presenting with oral allergy syndrome, Journal of Investigational Allergology and Clinical Immunology, 2005, 15,( 3), 228–229.
42. Gurley B.J., Swain A., Hubbard M.A., et al., Clinical assessment of CYP2D6-mediated herb–drug interactions in humans: Effects of St. John’s wort, garlic oil, and peppermint oil on debrisoquine metabolism, Drug Metabolism and Disposition, 2002, 30, (3), 377–382.
43. Grigoleit H.G., Grigoleit P., Pharmacology and preclinical pharmacokinetics of peppermint oil, Phytomedicine, 2005, 12, (8), 612–616.
44. Kennedy D.O., Scholey A.B., The psychopharmacology of European herbs with cognition-enhancing properties, Current Pharmaceutical Design, 2006, 12, (35), 4613–4623.
45. Posadzki P., Watson L., Ernst E., Herb–drug interactions: An overview of systematic reviews, British Journal of Clinical Pharmacology, 2013, 75, (3), 603–618.
46. Allied Market Research, Peppermint Oil Market Size, Share, Competitive Landscape and Trend Analysis Report, by Product Type, Application, Distribution Channel: Global Opportunity Analysis and Industry Forecast, 2021–2031, Allied Market Research Journal, 2022, Report Code: A14182, Pages: 262.
47. Market.US; Global Peppermint Oil Market By Source, Form, Method of Extraction, Application, End-use, Region and Companies - Industry Segment Outlook, Market Assessment, Competition Scenario, Trends, and Forecast 2024–2033; Market.US Report; 2024; Report ID: 134455, Pages: 282.
48. Taher YA; Antinociceptive activity of Mentha piperita leaf aqueous extract in mice; The Libyan Journal of Medicine; 2012; 7(0), 16205.
49. Al-Snaphi; Mentha piperita: Essential Oil and Extracts, Their Biological Activities, and Perspectives on the Development of New Medicinal and Cosmetic Products; Molecules; 2023; 28(21), 7444.
50. Rosmalena, Putri NA, Yazid F, Ambarwati NSS, Omar H, Ahmad I; Phytochemical, in vitro radical scavenging and in vivo oxidative stress analysis of peppermint (Mentha piperita L.) leaves extract; J Adv Technol Res; 2022; 13(2), 133-137.
51. Sowjanya pulapati, O. Sai Koushik, P. Srinivasa Babu; Phytochemical Analysis and Antibacterial Efficacy of Mentha piperita (L) Ethanolic Leaf Extract against Clinical Isolates of Uropathogens ; Biomedical Research; 2016; 13(6), 1-5.
52. Chandirasegaran. G, Elanchezhiyan. C, Suhasini. S, Babby A; Antihyperglycemic Activity of Mentha Piperita Ethanol Leaves Extract on Streptozotocin Induced Diabetic Rats; IJPRS; 2014; 3(3), 344.
53. Hanumanthachar Joshi, Mittal Bhadania ; Evaluation of Freeze Dried Extract of Mentha piperita in Management of Cognitive Dysfunctions in Mice; Alzheimer's & Dementia; 2014; 10(4, Suppl), 618.
54. Manel Srief, Moustafa Bani, El Hassen Mokrani, Imad Mennai, Mehdi Hamdi, Abdenour Boumechhour, Mohamed Abou Mustapha, Mouna Derdour, Messouad Kerkatou , Mohamed El-Shazly, Chawki Bensouici, Gema Nieto* and Salah Akkal ; Evaluation of In Vitro and In Silico Anti-Alzheimer Potential of Nonpolar Extracts and Essential Oil from Mentha piperita; Foods; 2023; 12(1), 190.
55. Wijaya. BK, Hardjo. PH, Emantoko. S; Menthol from the stem and leaf in-vitro Mentha piperita Linn.; IOP Conf. Ser.: Earth Environ. Sci.; 2019; 293(1), 012009.
56. 56.Para Sujanal, Thulasi Muneppa Sridhar, Penchalaneni Josthna, Challagundla Varadarajulu Naidu* ; Antibacterial Activity and Phytochemical Analysis of Mentha piperita L. (Peppermint)—An Important Multipurpose Medicinal Plant; American Journal of Plant Sciences; 2013; 4(1), 77-83.
57. A. Pradeepkumar, Kethireddy sravani, J. Ramya, V. Asha Jyothi, Antibacterial activity of various extracts of gymnema sylvestre and embelia ribes, IJPT, 2011, 3, 2, 2440-2451.
58. Ashajyothi. V, Dr. Rao. S. Pippalla and Dr. Satyavati D, Antioxidant activity of few phytoestogens by DPPH assay, IJPT, 2013, 5 | (3) p: 5868-5872.
59. Asha Jyothi. V, Giridhar Vedantam and Shahnaz Taskeena, what do you know about diabetes mellitus? IJPBCS, 13(3), 2024, p:06-19.
60. V. Asha Jyothi and K. Amtul Raouf Qazi, Hepatoprotective activity: recent update, IJPBCS, 14(2), 2025, p:01-19.
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