PREPARATION AND EVALUATION OF DOCETAXEL SOLID LIPID NANOPARTICLES FOR TARGETED DRUG DELIVERY TO BRAIN
Keywords:
Docetaxel drug, Lipids, FTIR, Emulsification technique, Solid lipid Nanoparticles, in vitro drug releaseAbstract
Docetaxel has low solubility and permeability, which result in limited and variable bioavailability; its low stability makes it difficult to develop stable aqueous liquid formulations. The Docetaxel solid lipid nanoparticles were created using the Sonicator to apply ultrasonic energy during the emulsification solvent evaporation process. The numerous formulations with varied drug-lipid and surfactant ratios were analyzed and improved. Docetaxel solid lipid nanoparticles containing soy lecithin were created using the solvent evaporation method, then the particle size was decreased by sonication. Particle size, surface morphology by SEM, drug excipient compatibility by FTIR, and in-vitro drug release experiments were used to characterize the produced nanosuspensions. The formulation with the best encapsulation efficiency was (F-4) A drug encapsulation effectiveness of up to 97.85% has been attained in this study. It was discovered that the efficiency of encapsulation improved along with the soy lecithin content.
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